Disease Areas

Friedreich Ataxia 

Woman with Friedreich Ataxia

Friedreich Ataxia (FA)

FA is a rare, serious, and progressive neurodegenerative disease that affects approximately 15,000 individuals globally and an estimated 1,000 Canadians.1,2 The most common form of hereditary ataxia, FA is caused by damage to the spinal cord, peripheral nerves, and the part of the brain that coordinates balance, movement and speech.1,3 

FA typically has early symptoms appearing in childhood or adolescence, which include poor coordination, muscle weakness, and fatigue.4 Many people with FA use walking aids and most will need to use a wheelchair within 10 to 20 years after diagnosis. Other symptoms of FA include vision and hearing impairment, scoliosis, diabetes, and difficulty with speech and swallowing and serious heart conditions.5

Our Approach

Biogen is proudly committed to supporting the unmet needs of the FA community and we will leverage our rare disease expertise and capabilities to help  Canadians who live with this devastating disease.

Living with FA: Emily's story

With her support system by her side, Emily, who was diagnosed with FA at age 15, is inspired to pursue the things she loves most.

Living with FA: Sam's story

Sam was diagnosed with FA at the age of 15. He loves to handcycle and watch/play sports.

Facts and Figures

1,000

The estimated number of Canadians who live with FA.2

 

 

37 years

The average life expectancy for people living with FA.6

 

 

10-20 years

Most people living with FA will need to use a wheelchair within 10-20 years of their first symptoms.7

 

References
  1. Friedreich's Ataxia Research Alliance - What is FA? (curefa.org). Accessed on: January 2024
  2. Michael S. Salman, Esther J. Lee, Anindita Tjahjadi, Bernard N. Chodirker. The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada. Developmental Medicine & Child Neurology. 2013 April; 55(4):341-347.  
  3. National Institute of Neurological Disorders and Stroke. Friedreich Ataxia. Available at: https://www.ninds.nih.gov/health-information/disorders/friedreich-ataxia. Accessed February 2025.  
  4. Fogel BL, Perlman S. Clinical features and molecular genetics of autosomal recessive cerebellar ataxias. Lancet Neurol. 2007 Mar;6(3):245-57. doi: 10.1016/S1474-4422(07)70054-6. PMID: 17303531.  
  5. Polek B, Roach MJ, Andrews WT, Ehling M, Salek S. Burden of Friedreich's Ataxia to the Patients and Healthcare Systems in the United States and Canada. Front Pharmacol. 2013 May 22;4:66. doi: 10.3389/fphar.2013.00066. PMID: 23734128; PMCID: PMC3660667.  
  6.  Parkinson MH, Boesch S, Nachbauer W, Mariotti C, Giunti P. Clinical features of Friedreich's ataxia: classical and atypical phenotypes. J Neurochem. 2013; 126 Suppl 1:103-17
  7.  Rummey C, Farmer JM and Lynch DR. Predictors of loss of ambulation in Friedreich's ataxia. E Clinical Medicine, 2020;18:100213

 

 

 

 

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